Fetal Dopaminergic Cell Suspension Grafts to Striatum in Aged Rats with Motor Disabilities
نویسندگان
چکیده
223 Aged rodents, like aged humans, exhibit a decline in sensory and motor functions, learning and memory /1/. The altered dopaminergic transmission in the nigrostriatal system is implicated in movement disorders and sensorimotor coordination disabilities associated with aging /2/.
منابع مشابه
Aged rats: recovery of motor impairments by intrastriatal nigral grafts.
Dissociated cell suspensions, prepared from the substantia nigra and septal regions of rat embryos, can be grafted to the depths of the caudate-putamen and hippocampus of aged rats. The grafts were rich in dopamine-containing and acetylcholinesterase-positive neurons and had produced extensive new dopaminergic and cholinergic terminal networks in the host neostriatum and hippocampus, respective...
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It is well known that fetal striatal tissue grafted into excitotoxically lesioned adult striatum can partially restore the behavioural/1/ and biochemical /3/ deficits, and establish anatomical connections with the host tissue/2,46/. Those previous studies were undertaken after grafting in acutely (usually 1 4 weeks before) lesioned striatum. Several factors change in the lesioned area after a l...
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The current transplantation paradigm for Parkinson's disease that places foetal dopaminergic cells in the striatum neither normalizes neuronal activity in basal ganglia structures such as the substantia nigra (SN) and subthalamic nucleus (STN) nor leads to complete functional recovery. It was hypothesized that restoration of parkinsonian deficits requires inhibition of the pathological overacti...
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ورودعنوان ژورنال:
- Journal of Neural Transplantation & Plasticity
دوره 3 شماره
صفحات -
تاریخ انتشار 1992